Article
Abnormal activation of cytokine gene expression by intracisternal type A particle transposition: effects of mutations that result in autocrine growth stimulation and malignant transformation.
Cytokines, cellular & molecular therapy - 1 Mar 1997
Wang X Y, Steelman L S, McCubrey J A
Abstract excerpt
This review will focus on understanding the mechanisms resulting in the deregulated expression of cytokine genes that can lead to autocrine transformation. The murine genome contains over 2000 copies of intracisternal type A particles (IAPs), which under certain circumstances can transpose to dif...
Topics
- Animals
- Cell Division
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cytokines
- DNA Transposable Elements
- Defective Viruses
- Gene Expression Regulation
- Genes, Intracisternal A-Particle
- Hematopoiesis
- Humans
- Interleukin-3
- Mice
- Models, Biological
- Mutation
- Oncogenes
- RNA, Messenger
- Receptors, Interleukin-3