Abnormal activation of cytokine gene expression by intracisternal type A particle transposition: effects of mutations that result in autocrine growth stimulation and malignant transformation.

Abstract excerpt

This review will focus on understanding the mechanisms resulting in the deregulated expression of cytokine genes that can lead to autocrine transformation. The murine genome contains over 2000 copies of intracisternal type A particles (IAPs), which under certain circumstances can transpose to different positions in the genome. When these transpositions affect the expression of a gene that can either positively or...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Division
• Share to Cell Transformation, Neoplastic