Article
In vivo transformation of factor-dependent hemopoietic cells: role of intracisternal A-particle transposition for growth factor gene activation.
The EMBO journal - 1 Apr 1990
Dührsen U, Stahl J, Gough N M
Abstract excerpt
Cells of the granulocyte-macrophage colony stimulating factor (GM-CSF) or multi-lineage colony stimulating factor (Multi-CSF) dependent line FDC-P1 undergo leukemic transformation after injection into irradiated DBA/2 mice. About one third of factor-independent FDC-P1 variants isolated from leuke...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Cell Transformation, Neoplastic
- Cloning, Molecular
- Colony-Stimulating Factors
- DNA
- Gene Expression Regulation
- Gene Rearrangement
- Genes
- Genes, Intracisternal A-Particle
- Genetic Variation
- Granulocyte-Macrophage Colony-Stimulating Factor
- Growth Substances