Article
Phenotypic changes induced by interleukin-2 (IL-2) and IL-3 in an immature T-lymphocytic leukemia are associated with regulated expression of IL-2 receptor beta chain and of protein tyrosine kinases LCK and LYN.
Blood - 15 Aug 1992
O'Connor R, Torigoe T, Reed J C, Santoli D
Abstract excerpt
We have previously reported the establishment of an interleukin-3 (IL-3)-dependent and phenotypically myeloid cell line (TALL-103/3), obtained by culturing cells from an immature T-lymphoblastic leukemia in the presence of IL-3. These cells differentiated into a T-lymphoid cell line (TALL-103/2)...
Topics
- Cell Division
- Gene Expression Regulation
- Humans
- Immunophenotyping
- Interleukin-2
- Interleukin-3
- Leukemia-Lymphoma, Adult T-Cell
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Phenotype
- Protein-Tyrosine Kinases
- RNA
- RNA, Messenger
- Receptors, Interleukin-2
- Tumor Cells, Cultured
- src-Family Kinases