Article
Use of NS-4 peptides to identify type-specific antibody to hepatitis C virus genotypes 1, 2, 3, 4, 5 and 6.
The Journal of general virology - 1 Jul 1995
Bhattacherjee V, Prescott L E, Pike I, Rodgers B, Bell H, El-Zayadi A R, Kew M C, Conradie J, Lin C K, Marsden H
Abstract excerpt
The 5' end of the NS-4 protein of different genotypes of hepatitis C virus (HCV) is highly variable in nucleotide and inferred amino acid sequence, with frequent predicted amino acid substitutions between all six of the major HCV genotypes described to date. This region has been shown to be antigenic by epitope mapping, and elicits antibody in HCV-infected individuals with a detectable type-specific component. We...
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