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Article

Antigenicity of key hepatitis C virus E1E2 glycoprotein neutralizing sites is genotype independent.

The Journal of general virology - 1 Jan 2026

Mimms Jessica L, Sinnis-Bourozikas Ariadne, Felbinger Nathaniel R, Frumento Nicole, Paul Harry T, Patel Arvind H, Keck Zhenyong, Foung Steven K H, Law Mansun, Urbanowicz Richard A, Tarr Alexander W, Ball Jonathan K, Pierce Brian G, Bailey Justin R

Abstract excerpt

The development of an effective prophylactic hepatitis C virus (HCV) vaccine is a priority to achieve global elimination of the virus. Accurate assessment of the neutralizing breadth of antibodies induced by vaccines and a clear understanding of the antigenic differences between viral variants included in vaccines are both critical for vaccine development. Prior studies have indicated that HCV genotypes (gts) do...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41527886
DOI: 10.1099/jgv.0.002201
PMCID: PMC12798819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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