Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defining Breadth of Hepatitis C Virus Neutralization.

Frontiers in immunology - 1 Jan 2018

Kinchen Valerie J, Bailey Justin R

Abstract excerpt

Extraordinary genetic diversity is a hallmark of hepatitis C virus (HCV). Therefore, accurate measurement of the breadth of antibody neutralizing activity across diverse HCV isolates is key to defining correlates of immune protection against the virus, and essential to guide vaccine development. Panels of HCV pseudoparticle (HCVpp) or replication-competent cell culture viruses (HCVcc) can be used to measure...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepacivirus
Share to Hepatitis C
Share to Antibodies, Monoclonal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibodies, Neutralizing

Share to Hepatitis C Antibodies

Share to Neutralization Tests

Share to Viral Envelope Proteins

Share to Viral Hepatitis Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 30116237
DOI: 10.3389/fimmu.2018.01703
PMCID: PMC6082923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defining Breadth of Hepatitis C Virus Neutralization.PMID 30116237Read ↗

A Diverse Panel of Hepatitis C Virus Glycoproteins for Use in Vaccine Research Reveals Extremes of Monoclonal Antibody Neutralization ResistanceSemantic proximity Read ↗

Antigenicity of key hepatitis C virus E1E2 glycoprotein neutralizing sites is genotype independent.Semantic proximity Read ↗

Repeated exposure to heterologous hepatitis C viruses associates with enhanced neutralizing antibody breadth and potencySemantic proximity Read ↗

Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a.Semantic proximity Read ↗

Viral evasion and challenges of hepatitis C virus vaccine development.Semantic proximity Read ↗

Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: genetic subtype defines antigenic but not neutralization serotype.Semantic proximity Read ↗

Broad Anti-Hepatitis C Virus (HCV) Antibody Responses Are Associated with Improved Clinical Disease Parameters in Chronic HCV Infection.Semantic proximity Read ↗

Naturally selected hepatitis C virus polymorphisms confer broad neutralizing antibody resistanceSemantic proximity Read ↗

Distinct mechanisms of antibody-mediated HCV neutralization revealed by nanobody-guided epitope mappingSemantic proximity Read ↗

Can Broadly Neutralizing Monoclonal Antibodies Lead to a Hepatitis C Virus Vaccine?Semantic proximity Read ↗

A Hepatitis C Virus Envelope Polymorphism Confers Resistance to Neutralization by Polyclonal Sera and Broadly Neutralizing Monoclonal AntibodiesSemantic proximity Read ↗

Hypervariable region 1 shielding of hepatitis C virus is a main contributor to genotypic differences in neutralization sensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.