Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploiting information inherent in binding sites of virus-specific antibodies: design of an HCV vaccine candidate cross-reactive with multiple genotypes.

Antiviral therapy - 1 Jan 2006

Grollo Lara, Torresi Joseph, Drummer Heidi, Zeng Weiguang, Williamson Nicholas, Jackson David C

Abstract excerpt

BACKGROUND/AIMS: The role of antibody in hepatitis C virus (HCV) infection remains unclear although many reports attest to its role in viral clearance. Here we describe epitopes that are recognized by antibody present in the serum of infected patients and show that such epitopes can induce neutralizing antibodies. METHODS: Human serum containing hyperimmune anti-HCV IgG was used to extract epitopes from a library...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Viral
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross Reactions

Share to Epitope Mapping

Share to Epitopes, B-Lymphocyte

Share to Hepatitis C

Share to Peptide Library

Share to Viral Hepatitis Vaccines

Source

Identifiers

PMID: 17302370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploiting information inherent in binding sites of virus-specific antibodies: design of an HCV vaccine candidate cross-reactive with multiple genotypes.PMID 17302370Read ↗

Hepatitis C virus E1 protein-specific linear B-cell epitopes, pan-genotype reactivity, and functional relevance.Semantic proximity Read ↗

Structure-based design of hepatitis C virus E2 glycoprotein improves serum binding and cross-neutralizationSemantic proximity Read ↗

Can Broadly Neutralizing Monoclonal Antibodies Lead to a Hepatitis C Virus Vaccine?Semantic proximity Read ↗

Distinct mechanisms of antibody-mediated HCV neutralization revealed by nanobody-guided epitope mappingSemantic proximity Read ↗

Recombinant hepatitis C virus envelope glycoprotein vaccine elicits antibodies targeting multiple epitopes on the envelope glycoproteins associated with broad cross-neutralization.Semantic proximity Read ↗

Identification of a Broadly Cross-Reacting and Neutralizing Human Monoclonal Antibody Directed against the Hepatitis C Virus E2 ProteinSemantic proximity Read ↗

Hepatitis C Virus (HCV) Infection May Elicit Neutralizing Antibodies Targeting Epitopes Conserved in All Viral GenotypesSemantic proximity Read ↗

From Structural Studies to HCV Vaccine Design.Semantic proximity Read ↗

A meta-analysis of the existing knowledge of immunoreactivity against hepatitis C virus (HCV).Semantic proximity Read ↗

Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus.Semantic proximity Read ↗

Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target themSemantic proximity Read ↗

Viral evasion and challenges of hepatitis C virus vaccine development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.