Article
Screening HCV genotype-specific epitope peptides based on conserved sequence analysis and B cell epitope prediction in HCV E2 region.
Immunologic research - 1 Feb 2018
Hua Rui, Jiang Xiaoyu, Qi Lingxia, Guan Shanshan, Kuai Ziyu, Qiao Yongbo, Xu Yan, Gong Xin, Shi Yuhua, Kong Wei, Niu Junqi, Zhang Hao, Shan Yaming
Abstract excerpt
The high mutation rate of the hepatitis C virus (HCV) genome increases the genotype diversity and renders the detection of the virus more difficult. Therefore, prediction and assessment of highly conserved and strongly antigenic epitope polypeptide sequences have become a focus of current research. The E2 region is the target binding region of neutralizing antibodies. HCV genomics, especially the high mutation...
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