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Article

Evidence of subtype-specific antibodies to antigenic epitopes in the NS5 region of hepatitis C virus in the circulation of patients with chronic hepatitis C.

Clinical and diagnostic laboratory immunology - 1 Sept 1994

Quiroga J A, Martin J, Pernas M, Pardo M, Herrero M, Castillo I, Bartolome J, Carreño V

Abstract excerpt

The antigenicity of the NS5 region of type 1 hepatitis C virus (HCV) was investigated by epitope mapping of the region spanning amino acids 2530 to 2723 of the HCV polyprotein. Six antigenic regions were recognized by anti-HCV positive sera from individuals with chronic hepatitis C in a modified enzyme-linked immunosorbent assay with synthetic oligopeptides. Five of these regions demonstrated intra-type 1...

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Identifiers

PMID: 8556499
DOI: 10.1128/cdli.1.5.545-551.1994
PMCID: PMC368335

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