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Article

Antigenic heterogeneity of the hepatitis C virus NS4 protein as modeled with synthetic peptides.

Virology - 25 Apr 1999

Chang J C, Seidel C, Ofenloch B, Jue D L, Fields H A, Khudyakov Y E

Abstract excerpt

The effect of sequence heterogeneity on the immunologic properties of two strong antigenic regions of the hepatitis C virus (HCV) NS4 protein was studied by using a set of 443 overlapping 20-mer synthetic peptides. One antigenic region comprising the cleavage site between NS4a and NS4b (region 5-1-1) was modeled with peptides derived from 73 different known sequences, representing HCV genotypes 1-6. The other...

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Identifiers

PMID: 10208931
DOI: 10.1006/viro.1999.9612

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