Article
Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice.
Development (Cambridge, England) - 1 Feb 1997
Coré N, Bel S, Gaunt S J, Aurrand-Lions M, Pearce J, Fisher A, Djabali M
Abstract excerpt
In Drosophila, the trithorax-group and the Polycomb-group genes are necessary to maintain the expression of the homeobox genes in the appropriate segments. Loss-of-function mutations in those groups of genes lead to misexpression of the homeotic genes resulting in segmental homeotic transformations. Recently, mouse homologues of the Polycomb-group genes were identified including M33, the murine counterpart of...
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