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Article

DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation.

Nature communications - 24 Mar 2016

Koya Junji, Kataoka Keisuke, Sato Tomohiko, Bando Masashige, Kato Yuki, Tsuruta-Kishino Takako, Kobayashi Hiroshi, Narukawa Kensuke, Miyoshi Hiroyuki, Shirahige Katsuhiko, Kurokawa Mineo

Abstract excerpt

Despite the clinical impact of DNMT3A mutation on acute myeloid leukaemia, the molecular mechanisms regarding how this mutation causes leukaemogenesis in vivo are largely unknown. Here we show that, in murine transplantation experiments, recipients transplanted with DNMT3A mutant-transduced cells exhibit aberrant haematopoietic stem cell (HSC) accumulation. Differentiation-associated genes are downregulated...

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Share to Bone Marrow Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

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Source

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Identifiers

PMID: 27010239
DOI: 10.1038/ncomms10924
PMCID: PMC4820786

Genes

PRC1
HOXA9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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