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Article

Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells.

PloS one - 1 Jan 2016

Si Sha, Nakajima-Takagi Yaeko, Aoyama Kazumasa, Oshima Motohiko, Saraya Atsunori, Sugishita Hiroki, Nakayama Manabu, Ishikura Tomoyuki, Koseki Haruhiko, Iwama Atsushi

Abstract excerpt

Polycomb-group RING finger proteins (Pcgf1-Pcgf6) are components of Polycomb repressive complex 1 (PRC1)-related complexes that catalyze monoubiquitination of histone H2A at lysine 119 (H2AK119ub1), an epigenetic mark associated with repression of genes. Pcgf5 has been characterized as a component of PRC1.5, one of the non-canonical PRC1, consisting of Ring1a/b, Rybp/Yaf2 and Auts2. However, the biological...

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Identifiers

PMID: 27136092
DOI: 10.1371/journal.pone.0154561
PMCID: PMC4852895

Genes

PRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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