Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.

Development (Cambridge, England) - 1 Oct 1997

Takihara Y, Tomotsune D, Shirai M, Katoh-Fukui Y, Nishii K, Motaleb M A, Nomura M, Tsuchiya R, Fujita Y, Shibata Y, Higashinakagawa T, Shimada K

Abstract excerpt

The rae28 gene is a mouse homologue of the Drosophila polyhomeotic gene (Nomura, M., Takihara, Y. and Shimada, K. (1994) Differentiation 57, 39-50), which is a member of the Polycomb group (Pc-G) of genes (DeCamillis, M., Cheng, N., Pierre, D. and Brock, H.W. (1992) Genes Dev. 6, 223-232). The Pc-G genes are required for the correct expression of the Homeotic complex genes and segment specification during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Gene Expression Regulation, Developmental

Share to Genotype

Source

Identifiers

PMID: 9367423
DOI: 10.1242/dev.124.19.3673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.PMID 9367423Read ↗

Positional cloning of a global regulator of anterior-posterior patterning in mice.Semantic proximity Read ↗

Polycomblike-2-deficient mice exhibit normal left-right asymmetry.Semantic proximity Read ↗

A functionally conserved Polycomb response element from mouse HoxD complex responds to heterochromatin factors.Semantic proximity Read ↗

Lack of the Polycomb-group gene rae28 causes maturation arrest at the early B-cell developmental stage.Semantic proximity Read ↗

Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain.Semantic proximity Read ↗

Functional analysis of mouse Polycomb group genes.Semantic proximity Read ↗

P-Element insertion at the polyhomeotic gene leads to formation of a novel chimeric protein that negatively regulates yellow gene expression in P-element-induced alleles of Drosophila melanogaster.Semantic proximity Read ↗

Mutations in polycombeotic, a Drosophila polycomb-group gene, cause a wide range of maternal and zygotic phenotypes.Semantic proximity Read ↗

Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice.Semantic proximity Read ↗

The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.Semantic proximity Read ↗

Misexpression of Polycomb-group proteins in Xenopus alters anterior neural development and represses neural target genes.Semantic proximity Read ↗

Direct interaction of the Polycomb protein with Antennapedia regulatory sequences in polytene chromosomes of Drosophila melanogaster.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.