Article
Genetic interactions and dosage effects of Polycomb group genes in mice.
Development (Cambridge, England) - 1 Sept 1998
Bel S, Coré N, Djabali M, Kieboom K, Van der Lugt N, Alkema M J, Van Lohuizen M
Abstract excerpt
In Drosophila and mouse, Polycomb group genes are involved in the maintenance of homeotic gene expression patterns throughout development. Here we report the skeletal phenotypes of compound mutants for two Polycomb group genes bmi1 and M33. We show that mice deficient for both bmi1 and M33 presen...
Topics
- Animals
- Apoptosis
- Bone and Bones
- Epistasis, Genetic
- Gene Dosage
- Gene Expression Regulation
- Genes, Homeobox
- In Situ Hybridization
- Mice
- Mice, Inbred BALB C
- Mutation
- Polycomb Repressive Complex 1
- Polycomb-Group Proteins
- Repressor Proteins
- Transcription Factors