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Article

Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth.

Molecular and cellular biology - 1 Aug 2006

Yae Kojiro, Keng Vincent W, Koike Masato, Yusa Kosuke, Kouno Michiyoshi, Uno Yoshihiro, Kondoh Gen, Gotow Takahiro, Uchiyama Yasuo, Horie Kyoji, Takeda Junji

Abstract excerpt

The Sleeping Beauty (SB) transposon system has generated many transposon-insertional mutant mouse lines, some of which have resulted in embryonic lethality when bred to homozygosity. Here we report one such insertion mapped to the mouse actin-related protein complex subunit 3 gene (Arpc3). Arpc3 is a component of the Arp2/3 complex, which plays a major role in actin nucleation with Y-shaped branching from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16880528
DOI: 10.1128/MCB.00018-06
PMCID: PMC1592801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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