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Article

Efficient strategies for genome scanning using maximum-likelihood affected-sib-pair analysis.

American journal of human genetics - 1 Mar 1997

Holmans P, Craddock N

Abstract excerpt

Detection of linkage with a systematic genome scan in nuclear families including an affected sibling pair is an important initial step on the path to cloning susceptibility genes for complex genetic disorders, and it is desirable to optimize the efficiency of such studies. The aim is to maximize power while simultaneously minimizing the total number of genotypings and probability of type I error. One approach to...

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PMID: 9042927
PMCID: PMC1712509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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