Optimal strategies for mapping complex diseases in the presence of multiple loci.

Article

Optimal strategies for mapping complex diseases in the presence of multiple loci.

American journal of human genetics - 1 May 1997

Goldgar D E, Easton D F

Abstract excerpt

Recent advances in genome technology have led to mapping and subsequent isolation, by positional cloning, of a number of genes for common and/or complex human diseases. It therefore will be possible to utilize information about a known locus in the search for additional, perhaps less penetrant, g...

Topics

Chromosome Mapping
Genetic Diseases, Inborn
Genetic Testing
Humans
Lod Score
Models, Genetic
Mutation
Nuclear Family
Research Design
Risk Factors
Sampling Studies
Sensitivity and Specificity

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