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Article

Optimal strategies for mapping complex diseases in the presence of multiple loci.

American journal of human genetics - 1 May 1997

Goldgar D E, Easton D F

Abstract excerpt

Recent advances in genome technology have led to mapping and subsequent isolation, by positional cloning, of a number of genes for common and/or complex human diseases. It therefore will be possible to utilize information about a known locus in the search for additional, perhaps less penetrant, genes for a particular disease. It is also unclear, under these situations, what the optimal sampling strategy should...

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PMID: 9150170
PMCID: PMC1712437

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