Power to detect linkage with heterogeneity in samples of small nuclear families.

doi:10.1002/ajmg.1320480208

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Article

Power to detect linkage with heterogeneity in samples of small nuclear families.

American journal of medical genetics - 15 Jul 1993

Levinson D F

Abstract excerpt

Computer simulation methods were used to investigate the power of genetically homogeneous or heterogeneous samples of nuclear families to detect linkage of a rare dominant disease allele to flanking DNA markers (three-point analysis, admixture text). Phase was assumed to be unknown (no grandparen...

Topics

Computer Simulation
Female
Genes, Dominant
Genetic Linkage
Genetic Markers
Genetic Variation
Genetics, Medical
Humans
Likelihood Functions
Lod Score
Male
Models, Genetic
Nuclear Family
Pedigree
Sampling Studies

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