Article
G-STRATEGY: Optimal Selection of Individuals for Sequencing in Genetic Association Studies.
Genetic epidemiology - 1 Sept 2016
Wang Miaoyan, Jakobsdottir Johanna, Smith Albert V, McPeek Mary Sara
Abstract excerpt
In a large-scale genetic association study, the number of phenotyped individuals available for sequencing may, in some cases, be greater than the study's sequencing budget will allow. In that case, it can be important to prioritize individuals for sequencing in a way that optimizes power for association with the trait. Suppose a cohort of phenotyped individuals is available, with some subset of them possibly...
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