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Article

A novel human multidrug resistance gene MDR1 variant G571A (G191R) modulates cancer drug resistance and efflux transport.

The Journal of pharmacology and experimental therapeutics - 1 Nov 2008

Yang Ziping, Wu Daniel, Bui Tot, Ho Rodney J Y

Abstract excerpt

The human multidrug resistance gene MDR1 encodes a membrane-bound transporter P-glycoprotein (Pgp) that confers the drug resistance of cancer cells by mediating an ATP-dependent drug efflux transport. We and others have reported a number of functionally significant MDR1 variants, including G1199A and G1199T, that modulate cancer drug resistance and intracellular levels of antivirals. In this report, we describe a...

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Identifiers

PMID: 18723777
DOI: 10.1124/jpet.108.138313
PMCID: PMC3477805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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