Article
Novel mechanism of resistance to paclitaxel (Taxol) in human K562 leukemia cells by combined selection with PSC 833.
Oncology research - 1 Jan 1995
Jaffrézou J P, Dumontet C, Derry W B, Durán G, Chen K G, Tsuchiya E, Wilson L, Jordan M A, Sikic B I
Abstract excerpt
A paclitaxel-resistant cell line, KPTA5, was established by co-selecting the parental erythroleukemic cell line K562 with stepwise increased concentrations of paclitaxel (Taxol) in the presence of the cyclosporin D analogue PSC 833 (2 microM), a potent modulator of the multidrug resistance phenot...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP-Binding Cassette Transporters
- Antineoplastic Combined Chemotherapy Protocols
- Base Sequence
- Cell Cycle
- Cell Nucleus
- Cyclosporins
- Drug Resistance, Multiple
- Humans
- Leukemia, Erythroblastic, Acute
- Mitosis
- Molecular Sequence Data
- Multidrug Resistance-Associated Proteins