Article
Multidrug resistance in cells transfected with human genes encoding a variant P-glycoprotein and glutathione S-transferase-pi.
Molecular pharmacology - 1 Jun 1990
Fairchild C R, Moscow J A, O'Brien E E, Cowan K H
Abstract excerpt
The nucleotide sequence of the mdr1 gene encoding a putative drug efflux pump (P-glycoprotein) is homologous to a class of bacterial membrane-associated transport proteins. These bacterial proteins are part of a multicomponent system that includes soluble periplasmic proteins that bind substrates, channeling them through the membrane in an energy-dependent manner. We have investigated the possibility that a...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Cell Line
- DNA
- Drug Resistance
- Gene Expression
- Genetic Variation
- Glutathione Transferase
- Humans
- Membrane Glycoproteins
- RNA, Messenger