Article
Multidrug resistance in a small cell lung cancer line: rapid selection with etoposide and differential chemosensitization with cyclosporin A.
Anti-cancer drugs - 1 Aug 1992
Glisson B S, Alpeter M D
Abstract excerpt
We developed a multidrug resistant small cell lung cancer line, VPR-2, by exposing H69 parent cells to etoposide (20 microM) for 1 h daily for 3 days every 21-28 days, a schedule similar to that used in the clinic. Resistance (20-fold) to the cytostatic and DNA cleavage activities of etoposide emerged after the third treatment, and this phenotype was stable in the absence of drug exposure for 2.5 years. VPR-2...
Topics
- Alkalies
- Biological Transport
- Carcinoma, Small Cell
- Cell Division
- Cell Nucleus
- Cyclosporine
- DNA Topoisomerases, Type II
- Drug Resistance
- Etoposide
- Lung Neoplasms
- Organelles