The Genomic Stability at the Coding Regions of the Multidrug Transporter Gene <i>ABCB1</i> : Insights into the Development of Alternative Drug Resistance Mechanisms in Human Leukemia Cells

Abstract excerpt

<h4>ABSTRACT</h4> Despite considerable efforts in reversing clinical multidrug resistance (MDR), targeting the predominant multidrug transporter ABCB1/P-glycoprotein (P-gp) based on small molecule inhibitors has been hindered. This may be due to the emergence of alternative drug resistance mechanisms. However, the non-specific P-gp inhibitor cyclosporine (CsA) showed significant clinical benefits in patients with...

Topics

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• Antigens, Differentiation, T-Lymphocyte
• ATP Binding Cassette Transporter, Subfamily B
• Drug Resistance, Multiple
• fas Receptor
• Interleukin-8
• Lectins, C-Type
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive
• Multidrug Resistance-Associated Proteins

Identifiers and source

Literature Corpus work

e4a074eb-3654-53e6-8066-661039f9a999

DOI

10.1101/820639