Article
Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1992
Eijdems E W, Borst P, Jongsma A P, de Jong S, de Vries E G, van Groenigen M, Versantvoort C H, Nieuwint A W, Baas F
Abstract excerpt
A non-P-glycoprotein-mediated mechanism of multidrug resistance (non-Pgp MDR) has been identified in doxorubicin-selected sublines of the human non-small cell lung carcinoma cell line SW-1573. These sublines are cross-resistant to daunorubicin, VP16-213, Vinca alkaloids, colchicine, gramicidin D,...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antineoplastic Agents
- Carcinoma, Non-Small-Cell Lung
- Cell Fusion
- Cell Line
- Cell Survival
- DNA Topoisomerases, Type II
- Daunorubicin
- Drug Resistance
- Gene Expression
- Humans
- Kinetics
- Lung Neoplasms