Article
Modulator activity of PSC 833 and cyclosporin-A in vincristine and doxorubicin-selected multidrug resistant murine leukemic cells.
Leukemia research - 1 Jan 2001
Lopes E C, Scolnik M, Alvarez E, Hajos S E
Abstract excerpt
Multidrug resistance (MDR) lines from a murine T-cell leukemia were selected in increasing vincristine (VCR) or doxorubicin (DOX) concentrations. Daunorubicin (DNR) efflux was evidenced after 25 additional passages with constant 160 ng ml(-1) of either VCR or DOX, an effect that was inhibited by verapamil, cyclosporin-A (CsA) and PSC 833. The expression of Pgp was not evidenced in the resistant cell lines using...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antibiotics, Antineoplastic
- Antineoplastic Agents, Phytogenic
- Biological Transport
- Cyclosporine
- Cyclosporins
- Doxorubicin
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Leukemia, T-Cell
- Mice
- Phenotype
- Tumor Cells, Cultured
- Vincristine