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Article

CG5/Dx human breast cancer cell line: characterization of a new doxorubicin-resistant variant.

Anticancer research - 1 Jan 2000

Gibelli N, Zibera C, Asti A, Maestri L, Bacchella L, Pedrazzoli P, Calligaro A, Robustelli della Cuna G

Abstract excerpt

By continuous exposure of CG5 human breast cancer cell line to increasing doxorubicin (Dx) concentrations, a multidrug-resistant (MDR) subline (CG5/Dx) was obtained. The resistant variant showed P-glycoprotein (P-gp) expression and a lower intracellular doxorubicin level than the parental cells. CG5/Dx cells were 19.4 fold more resistant to Dx than CG5 cells and showed a cross-resistance to some structurally...

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PMID: 8712686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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