Article
CG5/Dx human breast cancer cell line: characterization of a new doxorubicin-resistant variant.
Anticancer research - 1 Jan 2000
Gibelli N, Zibera C, Asti A, Maestri L, Bacchella L, Pedrazzoli P, Calligaro A, Robustelli della Cuna G
Abstract excerpt
By continuous exposure of CG5 human breast cancer cell line to increasing doxorubicin (Dx) concentrations, a multidrug-resistant (MDR) subline (CG5/Dx) was obtained. The resistant variant showed P-glycoprotein (P-gp) expression and a lower intracellular doxorubicin level than the parental cells....
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antibiotics, Antineoplastic
- Breast Neoplasms
- Cell Division
- Cell Line
- Cytoskeleton
- Doxorubicin
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Endoplasmic Reticulum, Rough
- Female
- Gene Expression
- Genetic Variation
- Humans
- Microscopy, Electron
- Mitochondria
- Polyribosomes