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Article

Mutational clusters generated by non-processive polymerases: A case study using DNA polymerase betain vitro.

DNA repair - 5 Aug 2010

García-Villada Libertad, Drake John W

Abstract excerpt

Available DNA mutational spectra reveal that the number of mutants with multiple mutations ("multiples") is usually greater than expected from a random distribution of mutations among mutants. These overloads imply the occurrence of non-random clusters of mutations, probably generated during episodes of low-fidelity DNA synthesis. Excess multiples have been reported not only for viruses, bacteria, and eukaryotic...

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Identifiers

PMID: 20627824
DOI: 10.1016/j.dnarep.2010.05.002
PMCID: PMC2914196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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