Article
Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta.
The Journal of biological chemistry - 17 Feb 2006
Venkatesan Ranga N, Hsu Jessica J, Lawrence Nicole A, Preston Bradley D, Loeb Lawrence A
Abstract excerpt
Eukaryotic DNA polymerase (Pol) delta replicates chromosomal DNA and is also involved in DNA repair and genetic recombination. Motif A in Pol delta, containing the sequence DXXXLYPSI, includes a catalytically essential aspartic acid as well as other conserved residues of unknown function. Here, we used site-directed mutagenesis to create all 19 amino acid substitutions for the conserved Leu(612) in Motif A of...
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