Characterization of DNA polymerase beta mutants with amino acid substitutions located in the C-terminal portion of the enzyme.

doi:10.1007/BF02190803

Back to search

Article

Characterization of DNA polymerase beta mutants with amino acid substitutions located in the C-terminal portion of the enzyme.

Molecular & general genetics : MGG - 28 Jul 1995

Sweasy J B, Yoon M S

Abstract excerpt

We used quantitative complementation assays to characterize individual DNA polymerase beta (Pol beta) mutants for their ability to function in DNA replication and DNA repair. We also describe a screen for detecting mutator activity of DNA polymerase beta mutants. By using these bioassays, togethe...

Topics

Animals
Blotting, Western
DNA Polymerase I
DNA Repair
DNA Replication
Escherichia coli
Genetic Complementation Test
Methyl Methanesulfonate
Mutagenesis
Mutation
Nitrous Acid
Phenotype
Rats

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.