The hepatitis B virus core and e antigens elicit different Th cell subsets: antigen structure can affect Th cell phenotype.

doi:10.1128/JVI.71.3.2192-2201.1997

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Article

The hepatitis B virus core and e antigens elicit different Th cell subsets: antigen structure can affect Th cell phenotype.

Journal of virology - 1 Mar 1997

Milich D R, Schödel F, Hughes J L, Jones J E, Peterson D L

Abstract excerpt

Secretion of the hepatitis B virus (HBV) e antigen (HBeAg) has been conserved throughout the evolution of hepadnaviruses. However, the function of this secreted form of the viral nucleoprotein remains enigmatic. It has been suggested that HBeAg functions as an immunomodulator. We therefore examin...

Topics

Adjuvants, Immunologic
Adoptive Transfer
Animals
Autoantibodies
B-Lymphocytes
Hepatitis B Antibodies
Hepatitis B Core Antigens
Hepatitis B e Antigens
Hepatitis B virus
Humans
Immunoglobulin G
Immunoglobulin Isotypes
Interferon-gamma
Interleukin-2
Interleukin-4
Mice
Mice, Inbred C57BL
Phenotype

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Identifiers

PMID: 9032353
DOI: 10.1128/JVI.71.3.2192-2201.1997
PMCID: PMC191326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9032353-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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