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Article

Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice

1 Aug 1997

Abstract excerpt

The pathogenetic effector functions of hepatitis B virus (HBV)-specific CD4+, Th1 cells were analyzed in two inbred lineages of HBV transgenic mice, one of which overexpresses the HBV large envelope protein rendering the hepatocytes hypersensitive to the cytopathic effects of IFN-gamma, and another that expresses all of the HBV proteins and replicates the virus in the liver. Transfer of HBV envelope-specific Th1...

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PMID: 9257867
DOI: 10.4049/jimmunol.159.4.2001

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