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Article

Type I Interferon Signaling Prevents Hepatitis B Virus-Specific T Cell Responses by Reducing Antigen Expression.

Journal of virology - 1 Dec 2018

Kawashima Keigo, Isogawa Masanori, Hamada-Tsutsumi Susumu, Baudi Ian, Saito Satoru, Nakajima Atsushi, Tanaka Yasuhito

Abstract excerpt

Robust virus-specific CD8+ T cell responses are required for the clearance of hepatitis B virus (HBV). However, the factors that determine the magnitude of HBV-specific CD8+ T cell responses are poorly understood. To examine the impact of genetic variations of HBV on HBV-specific CD8+ T cell responses, we introduced three HBV clones (Aa_IND [Aa], C_JPN22 [C22], and D_IND60 [D60]) that express various amounts of...

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Share to Antigen Presentation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hepatitis B Core Antigens

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Identifiers

PMID: 30209178
DOI: 10.1128/JVI.01099-18
PMCID: PMC6232490

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