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Article

A mechanism to explain the selection of the hepatitis e antigen-negative mutant during chronic hepatitis B virus infection.

Journal of virology - 1 Feb 2009

Frelin Lars, Wahlström Therese, Tucker Amy E, Jones Joyce, Hughes Janice, Lee Byung O, Billaud Jean-Noel, Peters Cory, Whitacre David, Peterson Darrell, Milich David R

Abstract excerpt

Hepatitis B virus (HBV) expresses two structural forms of the nucleoprotein, the intracellular nucleocapsid (hepatitis core antigen [HBcAg]) and the secreted nonparticulate form (hepatitis e antigen [HBeAg]). The aim of this study was to evaluate the ability of HBcAg- and HBeAg-specific genetic immunogens to induce HBc/HBeAg-specific CD4(+)/CD8(+) T-cell immune responses and the potential to induce liver injury...

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Source

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Identifiers

PMID: 19004949
DOI: 10.1128/JVI.01902-08
PMCID: PMC2620889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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