Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: experiences and findings.

doi:10.1016/j.jhep.2013.05.003

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Article

Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: experiences and findings.

Journal of hepatology - 1 Sept 2013

Xu Dao-Zhen, Wang Xuan-Yi, Shen Xin-Liang, Gong Guo-Zhong, Ren Hong, Guo Li-Min, Sun Ai-Min, Xu Min, Li Lan-Juan, Guo Xin-Hui, Zhen Zhen, Wang Hui-Fen, Gong Huan-Yu, Xu Cheng, Jiang Nan, Pan Chen, Gong Zuo-Jiong, Zhang Ji-Ming, Shang Jia, Xu Jie, Xie Qing, Wu Tie-Feng, Huang Wen-Xiang, Li Yong-Guo, Xu Jing, Yuan Zheng-Hong, Wang Bin, Zhao Kai, Wen Yu-Mei

Abstract excerpt

BACKGROUND & AIMS: Even though various experimental therapeutic approaches for chronic hepatitis B infection have been reported, few of them have been verified by clinical trials. We have developed an antigen-antibody (HBsAg-HBIG) immunogenic complex therapeutic vaccine candidate with alum as adjuvant (YIC), aimed at breaking immune tolerance to HBV by modulating viral antigen processing and presentation. A...

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PMID: 23669281
DOI: 10.1016/j.jhep.2013.05.003

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