Article
The phenotype of hepatitis B virus-specific T cells differ in the liver and blood in chronic hepatitis B virus infection.
Hepatology (Baltimore, Md.) - 1 Nov 2007
Chang J Judy, Thompson Alexander J V, Visvanathan Kumar, Kent Stephen J, Cameron Paul U, Wightman Fiona, Desmond Paul, Locarnini Stephen A, Lewin Sharon R
Abstract excerpt
UNLABELLED: Hepatitis B virus (HBV)-specific T cells play a key role in clearance of the virus and in the pathogenesis of liver disease. Peripheral blood (n = 25) and liver biopsies (n = 19) were collected from individuals with chronic untreated HBV infection. Whole blood, cultured peripheral blood mononuclear cells (PBMCs), and cultured liver-infiltrating lymphocytes (LILs) were each stimulated with an...
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