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Article

Immune tolerance split between hepatitis B virus precore and core proteins.

Journal of virology - 1 Mar 2005

Chen Margaret, Sällberg Matti, Hughes Janice, Jones Joyce, Guidotti Luca G, Chisari Francis V, Billaud Jean-Noel, Milich David R

Abstract excerpt

The function of the hepatitis B virus (HBV) precore or HBeAg is largely unknown because it is not required for viral assembly, infection, or replication. However, the HBeAg does appear to play a role in viral persistence. It has been suggested that the HBeAg may promote HBV chronicity by functioning as an immunoregulatory protein. As a model of chronic HBeAg exposure and to examine the tolerogenic potential of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15709022
DOI: 10.1128/JVI.79.5.3016-3027.2005
PMCID: PMC548461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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