Multiple regions of TBP participate in the response to transcriptional activators in vivo.

Abstract excerpt

We used mutant yeast and human TBP molecules with an altered DNA-binding specificity to examine the role of TBP in transcriptional activation in vivo. We show that yeast TBP is functionally equivalent to human TBP for response to numerous transcriptional activators in human cells, including those that do not function in yeast. Despite the extensive conservation of TBP, its ability to respond to transcriptional...

Topics

• Gene Expression Regulation
• Humans
• Models, Molecular
• Mutation
• RNA Polymerase II
• TATA Box
• Transcription Factor TFIID
• Transcription Factors
• Transcription, Genetic