Mutations on the DNA-binding surface of TATA-binding protein can specifically impair the response to acidic activators in vivo.

Abstract excerpt

The TATA-binding protein (TBP) contains a concave surface that interacts specifically with TATA promoter elements and a convex surface that mediates protein-protein interactions with general and gene-specific transcription factors. Biochemical experiments suggest that interactions between activator proteins and TBP are important in stimulating transcription by the RNA polymerase II machinery. To gain insight into...

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