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Article

Interdependent interactions between TFIIB, TATA binding protein, and DNA.

Molecular and cellular biology - 1 Dec 2002

Buratowski Robin M, Downs Jessica, Buratowski Stephen

Abstract excerpt

Temperature-sensitive mutants of TFIIB that are defective for essential interactions were isolated. One mutation (G204D) results in disruption of a protein-protein contact between TFIIB and TATA binding protein (TBP), while the other (K272I) disrupts an interaction between TFIIB and DNA. The TBP gene was mutagenized, and alleles that suppress the slow-growth phenotypes of the TFIIB mutants were isolated. TFIIB...

Topics

Alleles
DNA
Gene Expression Regulation, Fungal
Macromolecular Substances
Models, Molecular
Mutation
Nucleic Acid Conformation
Protein Binding
Protein Structure, Quaternary
Recombinant Proteins
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

TATA-Box Binding Protein

Temperature

Transcription Factor TFIIB

Source

Open in PubMed Open full text

Identifiers

PMID: 12446790
DOI: 10.1128/MCB.22.24.8735-8743.2002
PMCID: PMC139873

Genes

TBP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Interdependent interactions between TFIIB, TATA binding protein, and DNA.PMID 12446790Read ↗

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