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Article

Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain.

Nature - 27 Apr 1995

Chatterjee S, Struhl K

Abstract excerpt

Biochemical analyses have suggested potential targets for transcriptional activation domains, which include several components of the RNA polymerase II machinery, as well as the chromatin template. Here we examine the mechanism of transcriptional activation in yeast cells by connecting a heterologous DNA-binding domain (LexA) to the TATA-binding protein (TBP). LexA-TBP efficiently activates transcription from a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7723828
DOI: 10.1038/374820a0

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain.PMID 7723828Read ↗

The Drosophila TATA binding protein contains a strong but masked activation domain.Semantic proximity Read ↗

Mutations on the DNA binding surface of TBP discriminate between yeast TATA and TATA-less gene transcription.Semantic proximity Read ↗

Mutations on the DNA-binding surface of TATA-binding protein can specifically impair the response to acidic activators in vivo.Semantic proximity Read ↗

TBP-associated factors are not generally required for transcriptional activation in yeast.Semantic proximity Read ↗

Biochemical characterization of the TATA-binding protein-Gal4 activation domain complex.Semantic proximity Read ↗

A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo.Semantic proximity Read ↗

Site-specific cross-linking of TBP in vivo and in vitro reveals a direct functional interaction with the SAGA subunit Spt3.Semantic proximity Read ↗

Distinct classes of yeast promoters revealed by differential TAF recruitment.Semantic proximity Read ↗

A new regulatory domain on the TATA-binding protein.Semantic proximity Read ↗

Enhancement of TBP binding by activators and general transcription factors.Semantic proximity Read ↗

Genome-wide transcriptional dependence on conserved regions of Mot1.Semantic proximity Read ↗

Transcriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains.Semantic proximity Read ↗

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