Article
A new X-ray sensitive CHO cell mutant of ionizing radiation group 7,XR-C2, that is defective in DSB repair but has only a mild defect in V(D)J recombination.
Mutation research - 15 Sept 2000
Errami A, Overkamp W J, He D M, Friedl A A, Gell D A, Eckardt-Schupp F, Jackson S P, Hendrickson E A, Lohman P H, Zdzienicka M Z
Abstract excerpt
The DNA-dependent protein kinase (DNA-PK) complex plays a key role in DNA double-strand break (DSB) repair and V(D)J recombination. Using a genetic approach we have isolated cell mutants sensitive to ionizing radiation (IR) in the hope of elucidating the mechanism and components required for these pathways. We describe here, an X-ray-sensitive and DSB repair defective Chinese hamster ovary (CHO) cell line, XR-C2,...
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