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Article

Temperature sensitive mutants of influenza A virus generated by reverse genetics and clustered charged to alanine mutagenesis.

Virus research - 1 Dec 1996

Parkin N T, Chiu P, Coelingh K L

Abstract excerpt

Temperature sensitive (ts) mutants of influenza A virus have the potential to serve as live attenuated (att) virus vaccines. Previously, ts mutants were isolated by chemical mutagenesis or arose spontaneously, and most likely contained point mutations in one or more genes. While sufficiently attenuated, even the most genetically stable of these viruses was found to revert to a more virulent form in a seronegative...

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PMID: 9029775
DOI: 10.1016/s0168-1702(96)01373-1

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