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Article

Engineering temperature sensitive live attenuated influenza vaccines from emerging viruses.

Vaccine - 21 May 2012

Zhou Bin, Li Yan, Speer Scott D, Subba Anju, Lin Xudong, Wentworth David E

Abstract excerpt

The licensed live attenuated influenza A vaccine (LAIV) in the United States is created by making a reassortant containing six internal genes from a cold-adapted master donor strain (ca A/AA/6/60) and two surface glycoprotein genes from a circulating/emerging strain (e.g., A/CA/7/09 for the 2009/2010 H1N1 pandemic). Technologies to rapidly create recombinant viruses directly from patient specimens were used to...

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Identifiers

PMID: 22449422
DOI: 10.1016/j.vaccine.2012.03.025
PMCID: PMC3595159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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