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Article

Characterization of influenza A viruses with polymorphism in PB2 residues 701 and 702.

Scientific reports - 12 Sept 2017

Chin Alex W H, Leong Nathaniel K C, Nicholls John M, Poon Leo L M

Abstract excerpt

The 701 and 702 positions of influenza PB2 polymerase subunit are previously shown to have roles on host range. Limited polymorphisms at these two residues are identified in natural isolates, thereby limiting the study of their role in the polymerase. In this study, we generated 31 viable viruses by random mutagenesis at this region, indicating that these positions can tolerate a wide range of amino acids. These...

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Identifiers

PMID: 28900145
DOI: 10.1038/s41598-017-11625-y
PMCID: PMC5595998

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