Article
A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.
Viruses - 31 Oct 2020
Cox Andrew, Schmierer Jordana, D'Angelo Josephine, Smith Andrew, Levenson Dustyn, Treanor John, Kim Baek, Dewhurst Stephen
Abstract excerpt
Current influenza vaccines have modest efficacy. This is especially true for current live attenuated influenza vaccines (LAIV), which have been inferior to the inactivated versions in recent years. Therefore, a new generation of live vaccines may be needed. We previously showed that a mutation at PB1 residue 319 confers enhanced temperature sensitivity and attenuation in an LAIV constructed in the genetic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.