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Article

Genetically engineered live attenuated influenza A virus vaccine candidates.

Journal of virology - 1 Apr 1997

Parkin N T, Chiu P, Coelingh K

Abstract excerpt

We have generated new influenza A virus live attenuated vaccine candidates by site-directed mutagenesis and reverse genetics. By mutating specific amino acids in the PB2 polymerase subunit, two temperature-sensitive (ts) attenuated viruses were obtained. Both candidates have 38 degrees C shutoff temperatures in MDCK cells, are attenuated in the respiratory tracts of mice and ferrets, and have very low...

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Identifiers

PMID: 9060631
DOI: 10.1128/JVI.71.4.2772-2778.1997
PMCID: PMC191400

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