Genetically engineered live attenuated influenza A virus vaccine candidates.

doi:10.1128/JVI.71.4.2772-2778.1997

Back to search

Article

Genetically engineered live attenuated influenza A virus vaccine candidates.

Journal of virology - 1 Apr 1997

Parkin N T, Chiu P, Coelingh K

Abstract excerpt

We have generated new influenza A virus live attenuated vaccine candidates by site-directed mutagenesis and reverse genetics. By mutating specific amino acids in the PB2 polymerase subunit, two temperature-sensitive (ts) attenuated viruses were obtained. Both candidates have 38 degrees C shutoff...

Topics

Animals
Cell Line
Chickens
Dogs
Ferrets
Genetic Engineering
Humans
Influenza A virus
Influenza Vaccines
Influenza, Human
Mice
Mice, Nude
Mutagenesis, Site-Directed
Phenotype
RNA-Dependent RNA Polymerase
Temperature
Transfection
Vaccines, Attenuated

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.