Evaluation of the genetic stability of the temperature-sensitive PB2 gene mutation of the influenza A/Ann Arbor/6/60 cold-adapted vaccine virus.

doi:10.1128/JVI.68.12.7684-7688.1994

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Article

Evaluation of the genetic stability of the temperature-sensitive PB2 gene mutation of the influenza A/Ann Arbor/6/60 cold-adapted vaccine virus.

Journal of virology - 1 Dec 1994

Treanor J, Perkins M, Battaglia R, Murphy B R

Abstract excerpt

A single-gene reassortant bearing the PB2 gene of the A/Ann Arbor/6/60 cold-adapted virus in the background of the A/Korea/82 (H3N2) wild-type virus is a temperature-sensitive (ts) virus with an in vitro shutoff temperature of 38 degrees C. A single mutation at amino acid (aa) at 265 (Asp-Ser) of...

Topics

Amino Acid Sequence
Animals
Aspartic Acid
Base Sequence
Cell Line
Chick Embryo
Cold Temperature
Cricetinae
Dogs
Electrophoresis, Polyacrylamide Gel
Female
Genes, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Influenza A virus

Influenza Vaccines

Kidney

Mesocricetus

Mice

Mice, Inbred Strains

Source

Open in PubMed Open full text

Identifiers

PMID: 7966557
DOI: 10.1128/JVI.68.12.7684-7688.1994
PMCID: PMC237228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7966557-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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