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Article

Evaluation of the genetic stability of the temperature-sensitive PB2 gene mutation of the influenza A/Ann Arbor/6/60 cold-adapted vaccine virus.

Journal of virology - 1 Dec 1994

Treanor J, Perkins M, Battaglia R, Murphy B R

Abstract excerpt

A single-gene reassortant bearing the PB2 gene of the A/Ann Arbor/6/60 cold-adapted virus in the background of the A/Korea/82 (H3N2) wild-type virus is a temperature-sensitive (ts) virus with an in vitro shutoff temperature of 38 degrees C. A single mutation at amino acid (aa) at 265 (Asp-Ser) of the PB2 protein is responsible for the ts phenotype. This ts single-gene PB2 reassortant virus was serially passaged...

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Identifiers

PMID: 7966557
DOI: 10.1128/JVI.68.12.7684-7688.1994
PMCID: PMC237228

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