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Article

Mutation of neuraminidase cysteine residues yields temperature-sensitive influenza viruses.

Journal of virology - 1 Oct 1999

Basler C F, García-Sastre A, Palese P

Abstract excerpt

The influenza virus neuraminidase (NA) is a tetrameric, virus surface glycoprotein possessing receptor-destroying activity. This enzyme facilitates viral release and is a target of anti-influenza virus drugs. The NA structure has been extensively studied, and the locations of disulfide bonds within the NA monomers have been identified. Because mutation of cysteine residues in other systems has resulted in...

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Identifiers

PMID: 10482558
DOI: 10.1128/JVI.73.10.8095-8103.1999
PMCID: PMC112825

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